HIV - Aids

Efavirenz belongs to a class of antiretroviral medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It inhibits the replication of HIV, thereby reducing the amount of the virus in the blood. 

Naivex is an antiviral drug designed to treat HIV-1 infection in adults and children 12 years of age and weighing 40 kg or more as part of combination antiretroviral therapy. The drug is recommended for use in patients who have not received therapy ("naive"), and in patients with HAART. In some cases, it can be used in patients with partial resistance to integrase inhibitors.

Manufacturer - Hetero Ltd, India. The active substance is Dolutegravir. Dolutegravir in 2013-2014 is approved in many countries of the world as one of the components of highly active antiretroviral therapy, such as the USA, Canada, Mexico, Brazil, the EU, Russia, Japan, Australia, South Africa.

Dolutegravir inhibits HIV integration by binding to the active region of integrase and blocking the chain transfer during the integration of retroviral deoxyribonucleic acid (DNA), which is necessary for the HIV replication cycle. In vitro, dolutegravir is slowly separated from the active site of the wild-type DNA integrase complex (half-life of 71 hours).

Contraindications

- Hypersensitivity reactions to dolutegravir (and auxiliary substances). 
- Admission of anti-arrhythmic drug Dofetilide (English name Tikosyn) 
- Age is less than 12 years and body weight is less than 40 kg

Dolutegravir is rapidly absorbed after ingestion. The average time to reach the maximum concentration is 2-3 hours. When you take 1 time per day, the pharmacokinetic steady state is reached approximately 5 days after the beginning of the oral administration. Food increases the degree and reduces the rate of absorption of dolutegravir. These changes are generally clinically insignificant, so Instgra can be taken regardless of food intake. However, patients infected with HIV-1 with a certain resistance to integrase inhibitors are advised to take Naivex with food.

Co-infection with hepatitis C does not matter for the pharmacokinetics of dolutegravir. Data on co-infection with hepatitis B are limited.

Side effects

- Impaired immune system. Infrequently: a hypersensitivity reaction, a syndrome of a restoration of immunity. 
- Disorders of the psyche. Often: insomnia. 
- Disorders of the nervous system. Very often: a headache. Often: dizziness, unusual dreams. 
- Disorders of the digestive tract. Very often: nausea, diarrhea. Often: vomiting, flatulence, pain in the upper abdomen. Infrequent: pain in the abdomen, discomfort in the abdomen. 
- Disorders of the liver and biliary tract. Infrequently: hepatitis. 
- Impaired skin and subcutaneous tissue. Often: rash, itching. General disorders and disorders at the site of administration. Often: fatigue.

Interaction

- The simultaneous use of dolutegravir and other drugs that inhibit UDP-HT 1A1, UDF-GT1A3, UDF-GT1A9, CYP3A4 and/or Pgp, may increase the concentration of dolutegravir in blood plasma. 
- Contraindicated simultaneous reception with dofetilide. 
- The simultaneous use of dolutegravir and etravirine is not recommended unless the patient receives simultaneously atazanavir/ritonavir, lopinavir/ritonavir or darunavir/ritonavir. 
- The drug should not be administered together with antacids containing polyvalent cations. It is recommended to use dolutegravir 2 hours before or 6 hours after the application of these agents. 
- Dolutegravir may increase the concentrations of metformin. It is necessary to monitor patients during therapy, and metformin dosages may need to be adjusted.

Keep the drug in a dry place, protected from sun and inaccessible to children, at a temperature of 15 to 30 ° C. Date of manufacture and shelf life are indicated on the packaging.

• HIV infection
• Chronic hepatitis B virus (HBV) infection

This combination product is used with other HIV medications to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life. This product is a combination of 2 different drugs: lamivudine and tenofovir. Lamivudine is called a nucleoside reverse transcriptase inhibitor and tenofovir is called a nucleotide reverse transcriptase inhibitor. Lamivudine and tenofovir are often called NRTIs.

Lamivudine/tenofovir is not a cure for HIV infection. To decrease your risk of spreading HIV disease to others, do all of the following: (1) continue to take all HIV medications exactly as prescribed by your doctor, (2) always use an effective barrier method (latex or polyurethane condoms/dental dams) during all sexual activity, and (3) do not share personal items (such as needles/syringes, toothbrushes, and razors) that may have contacted blood or other body fluids. Consult your doctor or pharmacist for more details.

Zecyte Tablets manufactured by Cipla Pharma India contains Abiraterone Acetate as active ingredient in it. Abiraterone is a type of hormone therapy. It is also called abiraterone acetate,  or Zytiga. Abiraterone acetate is indicated for use in combination with prednisone for the treatment of men with metastatic castration-resistant prostate cancer.

Brand Name: Zecyte Tablets
Content: Abiraterone Acetate
Strength: 250 mg
Packing: Pack of 120 Tablets
Manufacturer: Cipla Pharma India
International Brand Name: Zytiga Tablets

Abamune-L is taken with other antiretroviral medications to treat adults infected with HIV-1. A single pill is the equivalent of 300mg of lamivudine IP and 600mg of abacavir. At least one other anti-HIV medication must be co-administered with Abamune-L to effectively prevent HIV from progressing to AIDS.

The recommended dose of Abamune-L for adults is one pill daily along with other antiretroviral medications. Abamune-L may be taken with or without food.

Any patient who has hepatic impairment should not take Abamune-L. Anyone with a prior history of hypersensitive reaction to abacavir or any of the other ingredients in Abamune-L should also not take the drug. Do not take any abacavir containing products after experiencing a hypersensitive reaction.

Taking Abamune-L has been associated with the following side effects:

• migraine
• rash
• nausea
• fatigue
• vomiting
• diarrhea
• gastritis
• abnormal dreams
• vertigo
• headache
• fever
• anxiety
• depression
• insomnia

In rare incidences, cases of fatal hypersensitive reactions to abacavir, a core ingredient of Abamune-L, have been reported. Other side effects may occur. Let a doctor know immediately if you feel any changes in your well being when you begin taking Abamune-L.