HIV - Aids

Naivex is an antiviral drug designed to treat HIV-1 infection in adults and children 12 years of age and weighing 40 kg or more as part of combination antiretroviral therapy. The drug is recommended for use in patients who have not received therapy ("naive"), and in patients with HAART. In some cases, it can be used in patients with partial resistance to integrase inhibitors.

Manufacturer - Hetero Ltd, India. The active substance is Dolutegravir. Dolutegravir in 2013-2014 is approved in many countries of the world as one of the components of highly active antiretroviral therapy, such as the USA, Canada, Mexico, Brazil, the EU, Russia, Japan, Australia, South Africa.

Dolutegravir user guide

 

Dolutegravir inhibits HIV integration by binding to the active region of integrase and blocking the chain transfer during the integration of retroviral deoxyribonucleic acid (DNA), which is necessary for the HIV replication cycle. In vitro, dolutegravir is slowly separated from the active site of the wild-type DNA integrase complex (half-life of 71 hours).

Contraindications

- Hypersensitivity reactions to dolutegravir (and auxiliary substances). 
- Admission of anti-arrhythmic drug Dofetilide (English name Tikosyn) 
- Age is less than 12 years and body weight is less than 40 kg

Dolutegravir is rapidly absorbed after ingestion. The average time to reach the maximum concentration is 2-3 hours. When you take 1 time per day, the pharmacokinetic steady state is reached approximately 5 days after the beginning of the oral administration. Food increases the degree and reduces the rate of absorption of dolutegravir. These changes are generally clinically insignificant, so Instgra can be taken regardless of food intake. However, patients infected with HIV-1 with a certain resistance to integrase inhibitors are advised to take Naivex with food.

Co-infection with hepatitis C does not matter for the pharmacokinetics of dolutegravir. Data on co-infection with hepatitis B are limited.

Side effects

 

- Impaired immune system. Infrequently: a hypersensitivity reaction, a syndrome of a restoration of immunity. 
- Disorders of the psyche. Often: insomnia. 
- Disorders of the nervous system. Very often: a headache. Often: dizziness, unusual dreams. 
- Disorders of the digestive tract. Very often: nausea, diarrhea. Often: vomiting, flatulence, pain in the upper abdomen. Infrequent: pain in the abdomen, discomfort in the abdomen. 
- Disorders of the liver and biliary tract. Infrequently: hepatitis. 
- Impaired skin and subcutaneous tissue. Often: rash, itching. General disorders and disorders at the site of administration. Often: fatigue.

Interaction

- The simultaneous use of dolutegravir and other drugs that inhibit UDP-HT 1A1, UDF-GT1A3, UDF-GT1A9, CYP3A4 and/or Pgp, may increase the concentration of dolutegravir in blood plasma. 
- Contraindicated simultaneous reception with dofetilide. 
- The simultaneous use of dolutegravir and etravirine is not recommended unless the patient receives simultaneously atazanavir/ritonavir, lopinavir/ritonavir or darunavir/ritonavir. 
- The drug should not be administered together with antacids containing polyvalent cations. It is recommended to use dolutegravir 2 hours before or 6 hours after the application of these agents. 
- Dolutegravir may increase the concentrations of metformin. It is necessary to monitor patients during therapy, and metformin dosages may need to be adjusted.

 

Keep the drug in a dry place, protected from sun and inaccessible to children, at a temperature of 15 to 30 ° C. Date of manufacture and shelf life are indicated on the packaging.

Abamune 300 mg tablet contains Abacavir 300 mg is used to treat HIV (human immunodeficiency virus) infection along with other medications.

Temirazer is a far reaching powerful antiretroviral sedate for the treatment of HIV-1 and HIV-2 contaminations in patients more than 18 years old.

Uses Atazanavir is used in combination with other anti-retroviral medicines for the treatment of human immunodeficiency virus (HIV-1) infection.How it works Atazanavir belongs to a group of medication called azapeptide HIV-1 protease inhibitor. It inhibits some viral polypeptides in the HIV-1 infected cells of the body and inhibits and prevents maturation of virus in the cells. Atazanavir does not cure HIV infections; it decreases the risks of developing acquired immunodeficiency syndrome (AIDS) and other HIV-related illnesses due to compromised immunity.

Common side effects
Kidney stone, Abnormal liver function tests, Cardiac conduction abnormalities, Bile duct stone, Depression, Diarrhoea, Fever, Glucose intolerance, Headache, Insomnia, Muscle pain, Nausea, Stomach pain, Vomiting Ritonavir(100 Mg)Uses Ritonavir is used along with other medication for treating human immunodeficiency virus (HIV 1) infection. It does not completely cure HIV or acquired immunodeficiency syndrome (AIDS).How it works Ritonavir belongs to a class of medication called protease inhibitors. It prevents HIV from multiplying inside the body.Common side effects Nausea, Tingling sensation of lip, Numbness of lip, Stomach upset, Vomiting

Emtricitabine(200 Mg)Uses Emtricitabine is used in the treatment of HIV infection How it works Emtricitabine belongs to class of medication called antiretroviral medicines. It works by inhibiting the enzyme needed for DNA synthesis (nucleoside reverse transcriptase) thereby lowering the growth and decrease the amount of HIV in body.Common side effects Nausea, Liver enzyme increased, Abdominal pain, Abnormal dreams, Hormone imbalance, Allergic reaction, Slow growth in children and teenagers, Diarrhoea, Dizziness, Eye swelling, Lip swelling, Headache, Increased glucose level in blood, Increased triglyceride level in blood, Increased creatine kinase level in blood, Indigestion, Insomnia, Rash, Itching, Vomiting, Pain, Weakness Tenofovir(300 Mg)Uses Tenofovir is used in the treatment of HIV infection and chronic hepatitis BHow it works Tenofovir is an antiviral drug belonging to class nucleoside reverse transcriptase inhibitors (NRTIs). Its  structure closely resembles the natural structure of viral DNA, that helps it to incorporate itself into the viral DNA. By doing so, it blocks the activity of an important viral enzyme reverse transcriptase which is involved in the replication of viral DNA, a process essential for survival of the virus.Common side effects Decreased white blood cell count (neutrophils), Peripheral neuropathy, Abdominal pain, Skin rash, Allergic reaction, Mood changes, Depression, Flatulence, Headache, Indigestion, Liver enzyme increased, Loss of appetite, Muscle pain, Weakness, Nausea, Diarrhoea Efavirenz(600 Mg)Uses Efavirenz is used in the treatment of HIV infection How it works

Efavirenz belongs to a class of antiretroviral medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It inhibits the replication of HIV, thereby reducing the amount of the virus in the blood. 

Common side effects Depression, Nightmare, Impaired concentration, Indigestion, Insomnia, Vomiting, Diarrhoea, Headache, Nervousness, Abdominal pain, Rash, Suicidal thoughts, Dizziness, Stomach upset, Confusion, Memory loss

MOQ 30 Tab

Lamivudine(150 Mg)Uses Lamivudine is used in the treatment of HIV infection and chronic hepatitis BHow it works Lamivudine prevents the multiplication of HIV virus in human cells. Thus stops the HIV virus from producing new viruses.Common side effects Fatigue, Headache, Nausea, Vomiting, Abdominal pain, Dizziness, Ear infection, Nasal infection, Throat infection, Sore throat, Skin rash, Muscle pain, Fever, Chills, Diarrhoea Zidovudine(300 Mg)Uses Zidovudine is used in the treatment of HIV infection How it works Zidovudine prevents the multiplication of HIV virus in human cells. Thus stops the HIV virus from producing new viruses.Common side effects Fatigue, Headache, Decreased appetite, Nausea, Vomiting, Muscle pain Nevirapine(200 Mg)Uses Nevirapine is used in the treatment of HIV infectionHow it works Nevirapine prevents the multiplication of HIV virus in human cells. Thus stops the HIV virus from producing new viruses.Common side effects Rash, Headache, Decrease in granulocyte count, Vomiting, Allergic reaction, Nausea, Abdominal pain, Fatigue, Fever, Increased liver enzymes, Diarrhoea

60 Tab

Abalam Tablet is a combination of two anti-HIV medicines: Abacavir and Lamivudine. They prevent HIV (virus) from multiplying, thereby reducing the amount of virus in your body. They also increase the CD4 cell (white blood cells that protect against infection) count in your blood.

Efavir Tablets. Efavir (Efavirenz) provides highly effective control and treatment of HIV-1 (human immunodeficiency virus) infections.

Nevivir 200 mg Tablet is an antiviral medicine which is used in combination with other medicines to treat human immunodeficiency virus (HIV) infection. This medicine is not a cure for HIV. It only prevents the virus from multiplying in your body. Close monitoring of liver function is necessary while receiving this medicine.

Ritocom Tablet is a combination medicine used to treat human immunodeficiency virus (HIV). This medicine is not a cure for HIV. It only prevents the virus from multiplying in your body. Monitoring of liver function and blood glucose levels is necessary while receiving this medicine.

TUDOFOVIR(Tenofovir Disoproxil Fumarate Tablets IP)COMPOSITIONEach film coated tablet contains:Tenofovir Disoproxil Fumarate IP 300 mgColours : Indigo Carmine & Titanium Dioxide

Zidolam Tablet is a combination medicine used to treat human immunodeficiency virus (HIV) infection. This medicine is not a cure for HIV. It only prevents the virus from multiplying in your body. Monitoring of liver function and kidney function may be necessary while receiving this medicine based on the clinical condition of the patient.

Tenof 300 mg Tablet is an antiviral medicine which is used to treat human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. This medicine is not a cure for HIV or HBV. It only prevents the virus from multiplying in your body. Close monitoring of liver function and kidney function is necessary while receiving this medicine.

Lamivudine(300 Mg)Uses Lamivudine indicated as part of antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infected adults and children and also used in the treatment of Hepatitis B virus infection.How it works Lamivudine belongs to a class of medication called nucleoside reverse transcriptase inhibitors. It decreases the amount of virus (HIV and hepatitis) in the blood. It also increases the number of infection-fighting cells in the body (CD4 cells). It does not cure HIV completely but reduces the chances of getting acquired immunodeficiency syndrome (AIDS) and HIV-related infections or cancer.Common side effects Neuropathy, Decreased white blood cell count (neutrophils), Pancreatic inflammation, Peripheral neuropathy, Abdominal cramp, Abdominal pain, Acne-like rash, Joint pain, Chills, Cough, Depression, Diarrhoea, Fever, Dizziness, Fatigue, Feeling of discomfort, Headache, Increased creatine phosphokinase level in blood, Increased blood urea, Indigestion, Insomnia, Stomatitis, Loss of appetite, Muscle pain, Redistribution/accumulation of body fat, Reduced blood platelets, Worsening of hepatitis b (viral infection of liver)Tenofovir(300 Mg)Uses Tenofovir is used in combination with other antiviral drugs in the treatment of human immunodeficiency virus (HIV) infections. It may also be used in very limited cases of long-term infections of the liver caused by hepatitis B virus.How it works Tenofovir is an antiviral drug belonging to class nucleoside reverse transcriptase inhibitors (NRTIs). Its structure closely resembles the natural structure of viral DNA, that helps it to incorporate itself into the viral DNA. By doing so, it blocks the activity of an important viral enzyme reverse transcriptase which is involved in the replication of viral DNA, a process essential for survival of the virus.Common side effects Decreased white blood cell count (neutrophils), Peripheral neuropathy, Abdominal pain, Skin rash, Allergic reaction, Mood changes, Depression, Flatulence, Headache, Indigestion, Liver enzyme increased, Loss of appetite, Muscle pain, Weakness, Nausea, DiarrhoeaEfavirenz(600 Mg)UsesEfavirenz is used in combination with other medications for the treatment of human immunodeficiency virus (HIV) infection.

How it works

Efavirenz belongs to a class of antiretroviral medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It inhibits the replication of HIV, thereby reducing the amount of the virus in the blood.

Common side effects Depression, Nightmare, Impaired concentration, Indigestion, Insomnia, Vomiting, Diarrhoea, Headache, Nervousness, Abdominal pain, Rash, Suicidal thoughts, Dizziness, Stomach upset, Confusion, Memory loss

Lamivudine(150 Mg) Uses Lamivudine is used in the treatment of hiv infection and chronic hepatitis b. How it works Lamivudine belongs to a class of medication called nucleoside reverse transcriptase inhibitors. It decreases the amount of virus (HIV and hepatitis) in the blood. It also increases the number of infection fighting cells in the body (CD4 cells). It does not cure HIV completely but reduces the chances of getting acquired immunodeficiency syndrome (AIDS) and HIV related infections or cancer.Common side effects Neuropathy, Decreased white blood cell count (neutrophils), Pancreatic inflammation, Peripheral neuropathy, Abdominal cramp, Abdominal pain, Acne-like rash, Joint pain, Chills, Cough, Depression, Diarrhoea, Fever, Dizziness, Fatigue, Feeling of discomfort, Headache, Increased creatine phosphokinase level in blood, Increased blood urea, Indigestion, Insomnia, Stomatitis, Loss of appetite, Muscle pain, Redistribution/ accumulation of body fat, Reduced blood platelets, Worsening of hepatitis b (viral infection of liver) Zidovudine (300 Mg) Uses Zidovudine is used in the treatment of HIV infection How it works Zidovudine belongs to a group of medications called nucleoside analogue reverse transcriptase inhibitors (NRTIs), also known as antiretrovirals. Zidovudine does not cure HIV infection; it reduces the amount of viruses in the body by inhibiting the enzyme (viral reverse transcriptase) which is essential for the virus to grow. Further, zidovudine also increases some white blood cells (CD4 cells) of the body that are important in fighting infections.Common side effects Abdominal pain, Altered sleep, Constipation, Diarrhoea, Dizziness, Headache.

Packaging Type: 60 Tablets
Dose/Strength (ex. 1 mg or 1 ml): Lamivudine 150 mg, Zidovudine 300 mg