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Dasakast 70 mg Tablet is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects.

Dasakast 70 mg Tablet can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Nausea, vomiting, abdominal pain and rash are some common side effects of this medicine. In some cases, it may cause increased heartbeat and low or high blood pressure, if it happens consult with your doctor. Your doctor might check your blood pressure regularly. It is advised to avoid antacid intake within 2 hours of taking this medicine. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. You must avoid driving if you experience dizziness or blurred vision during treatment.USES OF SPRYCEL TABLET

• Blood cancer (Chronic myeloid leukaemia)

SIDE EFFECTS OF SPRYCEL TABLETMost side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you are worried about themCommon side effects of Sprycel

• Abdominal pain
• Anemia (low number of red blood cells)
• Breathing problems
• Fatigue
• Fever
• Headache
• Infection
• Low blood platelets
• Musculoskeletal (bone, muscle or joint) pain
• Nausea
• Rash
• Vomiting

HOW TO COPE WITH SIDE EFFECTS?The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

• Coping with Abdominal painIn most cases, this is mild enough to be treated at home. Try to rest and relax. Putting a heat pad or covered hot water bottle on your stomach may also help. Having a warm bath or shower can help you relax and relieve the pain. Drink plenty of clear fluids such as water and reduce your intake of coffee, tea, lemon juice or soda. Avoid alcohol and smoking as these can aggravate the pain. Eating slowly and having smaller and more frequent meals can also help. If the pain is severe, speak to your doctor. They may be able to guide you better.

Entaliv 0.5 mg Tablet is an antiviral drug which is used in the treatment of chronic hepatitis B virus (HBV) infection in patients with severe liver abnormalities. It reduces the amount of virus in the patient's body, but it does not cure the disease. This medicine also may not prevent the complications of hepatitis B like liver cirrhosis. It also does not prevent the spread of HBV to other people.

SOFOSBUVIR + VELPATASVIR COMPOSITION 

Evergraf 0.25Mg Tablet is included in a class of medications called kinase inhibitors that treats cancer by stopping cancer cells from reproducing and cutting off blood supply to the cancer cells. Evergraf 0.25Mg Tablet decreases the action of the immune system. This may result in increased risk of developing infection or certain types of cancer such as lymphoma, skin cancer, etc.

Rivofonet 300 mg Tablet is an antiviral medicine which is used to treat human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. This medicine is not a cure for HIV or HBV. It only prevents the virus from multiplying in your body. Close monitoring of liver function and kidney function is necessary while receiving this medicine.

Sevcar 400 MG Tablet is used to lower the elevated phosphate levels in the blood by preventing its absorption in the intestine. It is used in severe kidney disease patients. Do not take this medicine if you have any gastrointestinal diseases.

Ibrutinib is used to treat chronic lymphocytic leukemia (CLL), Waldenström''''s macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease.^[5][3]

In the United States ibrutinib is indicated for the treatment of adults with mantle cell lymphoma (MCL) who have received at least one prior therapy, adults with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) with or without 17p deletion, adults with Waldenström''''s macroglobulinemia (WM), adults with marginal zone lymphoma (MZL) who require systemic therapy and have received at least one prior anti-CD20-based therapy, adults with chronic graft versus host disease (cGVHD) after failure of one or more lines of systemic therapy.^{[3][6][7][8][9]}

It is a first line treatment in those with CLL who require treatment and are newly diagnosed.^[10] It may also be used in CLL that relapses.^[10]

Resistance[edit]

Both primary (inherent) and secondary (acquired) resistance has been reported in various lymphomas, including CLL and MCL.^[11] Resistance may arise due to mutations that impair the affinity of ibrutinib for BTK, or due to alterations in pathways downstream of BTK and may confer BCR signaling independence in resistant clones.

Adverse effects[edit]

Very common (>10% frequency) adverse effects include pneumonia, upper respiratory tract infection, sinusitis, skin infection, low neutrophil count, low platelet counts, headache, bleeding, bruising, diarrhea, vomiting, inflammation of mouth and lips, nausea, constipation, rash, joint pain, muscle spasms, musculoskeletal pain, fever, and edema.^[5]

Common (1–10% frequency) adverse effects include sepsis, urinary tract infection, non-melanoma skin cancer (basal-cell carcinoma, squamous cell carcinoma), low leukocyte count, low lymphocyte count, interstitial lung disease, tumor lysis syndrome, high uric acid levels, dizziness, blurred vision, atrial fibrillation, subdural hematoma, nosebleeds, small bruises from broken blood vessels, high blood pressure, hives, and skin redness or blushing.^[5]

Revlamer 400 MG Tablet is used to lower the elevated phosphate levels in the blood by preventing its absorption in the intestine. It is used in severe kidney disease patients. Do not take this medicine if you have any gastrointestinal diseases.

Sevelamer is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease.