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Ibrutinib is used to treat chronic lymphocytic leukemia (CLL), Waldenström''''s macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, marginal zone lymphoma, and chronic graft vs host disease.^[5][3]

In the United States ibrutinib is indicated for the treatment of adults with mantle cell lymphoma (MCL) who have received at least one prior therapy, adults with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) with or without 17p deletion, adults with Waldenström''''s macroglobulinemia (WM), adults with marginal zone lymphoma (MZL) who require systemic therapy and have received at least one prior anti-CD20-based therapy, adults with chronic graft versus host disease (cGVHD) after failure of one or more lines of systemic therapy.^{[3][6][7][8][9]}

It is a first line treatment in those with CLL who require treatment and are newly diagnosed.^[10] It may also be used in CLL that relapses.^[10]

Resistance[edit]

Both primary (inherent) and secondary (acquired) resistance has been reported in various lymphomas, including CLL and MCL.^[11] Resistance may arise due to mutations that impair the affinity of ibrutinib for BTK, or due to alterations in pathways downstream of BTK and may confer BCR signaling independence in resistant clones.

Adverse effects[edit]

Very common (>10% frequency) adverse effects include pneumonia, upper respiratory tract infection, sinusitis, skin infection, low neutrophil count, low platelet counts, headache, bleeding, bruising, diarrhea, vomiting, inflammation of mouth and lips, nausea, constipation, rash, joint pain, muscle spasms, musculoskeletal pain, fever, and edema.^[5]

Common (1–10% frequency) adverse effects include sepsis, urinary tract infection, non-melanoma skin cancer (basal-cell carcinoma, squamous cell carcinoma), low leukocyte count, low lymphocyte count, interstitial lung disease, tumor lysis syndrome, high uric acid levels, dizziness, blurred vision, atrial fibrillation, subdural hematoma, nosebleeds, small bruises from broken blood vessels, high blood pressure, hives, and skin redness or blushing.^[5]

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It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS

It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS 

Viagra 100mg Tablet is a prescription medicine used to treat erectile dysfunction (impotence) in men. It works by increasing blood flow to the penis. This helps men to get or maintain an erection.

Tadacip 20 Tablet is used to treat erectile dysfunction in men. It increases blood flow to the penis to help men get an erection.

Imutrex 7.5 Tablet is a medicine used to treat rheumatoid arthritis where it can prevent further joint damage. It is also used to treat severe forms of a skin disease called psoriasis

Intacept 50 Injection is an immunosuppressive agent used to treat autoimmune diseases like rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis, and juvenile idiopathic arthritis. This medicine is not recommended for use in patients with active serious infections.

Bortero Injection is used in the treatment of multiple myeloma and mantle-cell lymphoma. It shows its working by stopping or slowing down the growth of cancer cells.

Caverject is indicated for the treatment of erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed aetiology

Amalaki helps boost immunity by building the body's natural defense system to fight infections. The active constituents of Amalaki has antioxidant effects that help rid the body of cell damaging free radicals. Amalaki rejuvenates the skin and delay premature skin aging.

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Velacar 400Mg Tablet acts as a phosphate binder, thus reducing the quantity of phosphorous that exists in the blood of kidney patients who are undergoing dialysis. The drug binds with the phosphorous thus reducing the quantity of phosphorous that is absorbed by the body.