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HEPATITIS C

Hepatitis C is a contamination that for the most part influences the liver. The hepatitis C infection (HCV) causes this sickness. Frequently, a man with Hepatitis C does not have any indications (medical issues or signs that he has the ailment). In any case, ceaseless contamination can scar the liver. Numerous years of disease may bring about cirrhosis. Infrequently, individuals with cirrhosis additionally have liver disappointment or liver tumor. They can likewise have extremely swollen veins of the throat and stomach. The blood misfortune from this issue can execute.

Hepatitis C is typically spread by blood-to-blood contact (when blood from a man with Hepatitis C contacts (touches or gets into) someone else's circulatory system). The most well-known ways this happens are through intravenous medication utilize (when a man shoots drugs into one of their veins, with a needle that was at that point utilized by a man contaminated with Hepatitis C); nonsterile restorative hardware (therapeutic devices that were not cleaned all around ok in the wake of being utilized on a tainted individual); and blood transfusions (when a man is given blood that originated from a contaminated individual)

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Hepcinat Plus
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Hepcinat Plus

Approx. Price: Rs 7,500 / BottleGet Latest Price
Product Details:
Pack size28 TABLETS
BrandHEPCINAT
ManufacturerNATCO
CompositionDACLATASVIR 60MG,SOFOSBUVIR 400MG
Prescription/Non prescriptionPrescription
FormTablet
Daclatasvir is an antiviral medication. It works by lowering a load of hepatitis C virus in the body and removing the virus from the blood over a period of time.

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  • Packaging Details: 28 TABLETS
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Velpanat
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Velpanat

Approx. Price: Rs 12,000 / BottleGet Latest Price
Product Details:
Pack size28 TABS
BrandVELPANAT
ManufacturerNATCO
CompositionVELPATASVIR 100MG,SOFOSBUVIR 400MG
TreatmentHEP C
Prescription/Non prescriptionPrescription
FormTablet
Velpanat 400mg/100mg Tablet is used in combination with other medications such as ribavirin, daclatasvir and peginterferon to treat chronic hepatitis C. It functions by reducing the hepatitis C virus in the body. This helps to keep liver disorders such as cirrhosis and liver cancer at bay.

Additional Information:
  • Packaging Details: 28 TABLETS
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Sofokast Daclakast
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Sofokast Daclakast

Approx. Price: Rs 6,000 / BottleGet Latest Price
Product Details:
Pack size28 TABLETS,28 TABLETS
BrandSOFOKAST DACIKAST
ManufacturerAPRAZER
CompositionSOFOSBUVIR DACLATASVIR
TreatmentHEP C
Prescription/Non prescriptionPrescription
FormTablet

Daclatasvir 400 mg +Sofosbuvir 90 mg is used in the treatment of chronic hepatitis C virus (HCV) infection.


Additional Information:
  • Packaging Details: 28 TABS SOFOSBUVIR, 28 TABS DACLATASVIR
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Tenohep
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Tenohep

Approx. Price: Rs 1,000 / BoxGet Latest Price
Product Details:
ManufacturerCadila Healthcare Ltd (Zydus)
CompositionTenofovir
TreatmentHepatitis B
Prescription/Non prescriptionPrescription
Packaging Size10 tablets (10/strip)
FormTablet
BrandTenohep
Tenohep 300 mg Tablet is an antiviral medicine which is used to treat human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. This medicine is not a cure for HIV or HBV. It only prevents the virus from multiplying in your body. Close monitoring of liver function and kidney function is necessary while receiving this medicine.

Additional Information:
  • Packaging Details: 10 tablets ( 10 / strip)
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HEPCDAC
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HEPCDAC

Approx. Price: Rs 1,500 / BottleGet Latest Price
Product Details:
Pack size28 TABLETS
BrandHEPCDAC
ManufacturerCipla Ltd
CompositionDACLATASVIR
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
FormTablet
Hepcdac Tablet is an antiviral medication used for the treatment of chronic hepatitis C in adults. It is normally used in a combination with sofosbuvir, with or without ribavirin. However, this medicine is not recommended for use as a preventive option for the spread of hepatitis C.

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Hepcvel
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Hepcvel

Approx. Price: Rs 9,000 / BottleGet Latest Price
Product Details:
Pack size28 tablets
Brandhepcvel
ManufacturerCipla Ltd
CompositionSofosbuvir 400mg + Velpatasvir 100mg
TreatmentHEP C
Prescription/Non prescriptionPrescription
FormTablet
Sofosbuvir is used in the treatment of chronic hepatitis C virus (HCV) infection.
Velpatasvir works by lowering a load of hepatitis C virus in the body and removing the virus from the blood over a period of time.

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  • Packaging Details: 28 TABLETS
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Velpaclear
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Velpaclear

Approx. Price: Rs 8,500 / BottleGet Latest Price
Product Details:
Pack size1*28 TABLETS
BrandVELPACLEAR
ManufacturerABBOTT
CompositionSofosbuvir + velpatasvir
TreatmentHepatitis c
Prescription/Non prescriptionPrescription
FormTablet
Velpaclear Tablet is a combination of two antiviral medicines: Sofosbuvir and Velpatasvir. They work by lowering the amount of hepatitis C virus in the body and removing the virus from the blood over a period of time.

Additional Information:
  • Delivery Time: 2-3 days
  • Packaging Details: 28 tablets
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Daclacure
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Daclacure

Approx. Price: Rs 1,500 / BottleGet Latest Price
Product Details:
Packaging Size28 Tablets
Dose/Strength (ex. 1 mg or 1 ml)60 MG
Pack size28 TAB
BrandDACLACURE
ManufacturerEMCURE
CompositionDACLATASVIR 60 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
We are extremely engrossed in exporting, retailing, wholesaling and supplying a premium quality DACLACURE Tablet. The offered tablet is processed utilizing superior quality chemical compounds and the latest technology in compliance with industry norms. The offered tablet, when used in combination with sofosbuvir, may result in a slowing of the heart rate. Apart from this, we offer this tablet in various packaging options so as to maintain its long shelf life.

Features:


  • 100% safe
  • Safe to consume
  • Free from impurities


Other Details: 28 Tablets


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Ledifos Tablets
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Ledifos Tablets

Approx. Price: Rs 5,600 / BottleGet Latest Price
Product Details:
Pack Size28 Tablets
Dose/Strength (mg or ml)90 mg + 400
BrandLEDIFOS
ManufacturerHETERO
CompositionSOFOSBUVIR 400 MG AND LEDIPASVIR 90 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
Other Details:

  • Ledifos Tablets contains Ledipasvir and Sofosbuvir a formulation combination of anti-viral medications used in the treatment of Chronic Hepatitis C Virus (CHC) infection genotype 1
  • Ledifos is a prescription medicine containing Ledipasvir (90mg) a viral NS5A inhibitor and Sofosbuvir (400mg) a nucleotide inhibitor of the viral RNA polymerase

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Sovihep V Tablets
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Sovihep V Tablets

Approx. Price: Rs 9,000 / BottleGet Latest Price
Product Details:
Minimum Order Quantity1 Bottle
Pack Size28 Tab
BrandSOVIHEP V
ManufacturerCadila Healthcare Ltd (Zydus)
CompositionSOFOSBUVIR 400 MG & VELPATASVIR 100 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
Strength/Dose (in mg or ml)SOFOSBUVIR 400 MG & VELPATASVIR 100 MG
Product TypeFinish Product
FormTablet
Shelf life2021
Indication:

Sofosbuvir With Velpatasvir is a two-drug combination for the treatment of hepatitis C. It is administered as a single daily pill containing the viral NS5A inhibitor velpatasvir and sofosbuvir, a nucleotide inhibitor of the viral RNA polymerase. It is the first treatment, that works for all genotypic, and is taken entirely by mouth. A single tablet regimen is used for adults with genotype 1-6 chronic hepatitis C virus (HCV) infection.

Mechanism of action:

Sofosbuvir With Velpatasvir is an oral fixed-dose combination of sofosbuvir, a nucleotide analog NS5B polymerase inhibitor and velapatasvir, an NS5A replication complex inhibitor. Sofosbuvir is approved for the treatment of genotype 1, 2, 3 and 4 HCV infection with different regimens and durations dependent on the HCV genotype. Velpatasvir (formerly GS-5816) is a novel NS5A inhibitor that has potent invitro anti-HCV activity across all genotypes at the picomolar level. The combination of sofosbuvir-velpatasvir is the first once-daily single-tablet regimen with pangenotypic activity.

Dosage and Administration:

Sofosbuvir With Velpatasvir is available as a coformulated, once-daily single-pill combination of sofosbuvir 400 mg and velpatasvir 100 mg. The recommended dose is one tablet once daily, taken with or without food.

  • Renal Impairment: For patients with mild to moderate renal impairment, no dosage adjustment of sofosbuvir-velpatasvir is recommended. There are insufficient data regarding the safety and efficacy of sofosbuvir-velpatasvir in patients with severe renal impairment (eGFR less than 30 ml/min/1.73m2) or end-stage renal disease requiring hemodialysis. Accordingly, no dosage recommendation has been given for patients with severe renal impairment or end-stage renal disease requiring dialysis.
  • Hepatic Impairment: For patients with mild, moderate, or severe hepatic impairment (Child-Pugh Class A, B, or C), no dosage adjustment for sofosbuvir-velpatasvir is recommended. For patients with decompensated cirrhosis who are receiving sofosbuvir-velpatasvir and ribavirin, clinical and laboratory monitoring is recommended.
Precaution:

Risk of Serious Symptomatic Bradycardia When Sofosbuvir Is Coadministered with Amiodarone and Another HCV Direct Acting Antiviral: Amiodarone is not recommended for use with Sofosbuvir With Velpatasvir due to the risk of symptomatic bradycardia, particularly in patients also taking beta blockers or with underlying cardiac comorbidities and/or with advanced liver disease. In patients without alternative, viable treatment options, cardiac monitoring is recommended. Patients should seek immediate medical evaluation if they develop signs or symptoms of bradycardia.

Risk of Reduced Therapeutic Effect Due to Concomitant Use of Sofosbuvir With Velpatasvir with P-gp Inducers and/or Moderate to Potent Inducers of CYP2B6, CYP2C8 or CYP3A4: Rifampin, St. John’s wort, and carbamazepine are not recommended for use with Sofosbuvir With Velpatasvir as they may significantly decrease sofosbuvir and/or velpatasvir plasma concentrations.


Additional Information:
  • Delivery Time: 1 DAY DELIVERY
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Hepcinat-LP
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Hepcinat-LP

Approx. Price: Rs 8,000 / BottleGet Latest Price
Product Details:
Pack Size28 Tablets
Dose/Strength (mg or ml)400 mg
BrandHEPCINAT LP
ManufacturerNATCO
CompositionSOFOSBUVIR 400 MG AND LEDIPASVIR 90 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription

With our in-depth knowledge and rich industry experience in this field, we are highly engaged in exporting, retailing, wholesaling and supplying a qualitative Hepcinat-Lp Tablet for our esteemed clients. Processed employing advanced technology and using premium quality chemical compounds, offered tablet should only be used under proper medical guidance and advice. In order to maintain the effectiveness, our quality examiners test this tablet on various parameters. 

Features:

  • Highly effective
  • Long shelf life
  • Balanced composition

 

Other Details: 28 Tablets.


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Natdac Tablet
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Natdac Tablet

Approx. Price: Rs 1,500 / BottleGet Latest Price
Product Details:
Packaging Size28 tablets
Dose/Strength (ex. 1 mg or 1 ml)60 mg
UsageClinical, Hospital
Pack size28 TAB
BrandNATDAC
ManufacturerNATCO
CompositionDACLATAVSIR 60 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription

With our in-depth knowledge and rich industry experience in this field, we are highly engaged in exporting, retailing, wholesaling and supplying a qualitative NATDAC Tablet for our esteemed clients. Processed employing advanced technology and using premium quality chemical compounds, offered tablet should only be used under proper medical guidance and advice. In order to maintain the effectiveness, our quality examiners test this tablet on various parameters. 

Features:

  • Highly effective
  • Long shelf life
  • Balanced composition

 

Other Details: 28 Tablets.


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Sovihep Tablets
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Sovihep Tablets

Approx. Price: Rs 3,500 / BottleGet Latest Price
Product Details:
Pack Size28 Tablets
Strength/Dose (in mg or ml)400 mg
Product TypeFinish Product
BrandSOVIHEP
ManufacturerCadila Healthcare Ltd (Zydus)
CompositionSOFOSBUVIR 400 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
Other Details:

  • SoviHep (Sofosbuvir) which is a drug used as part of antiviral therapy against chronic hepatitis C virus, this drug is directly targets the Hep C virus to stop it from making copies of itself in the liver and makes it harder for the virus to multiply
  • SoviHep (Sofosbuvir) must be used in combination with other HCV medications such as Pegylated and Ribavirin

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Ledihep Tablets
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Ledihep Tablets

Approx. Price: Rs 5,000 / BottleGet Latest Price
Product Details:
Minimum Order Quantity1 Bottle
Packaging Size28 Tablets
Dose/Strength (ex. 1 mg or 1 ml)400 mg
Pack size28 TAB
BrandLEDIHEP
ManufacturerCadila Healthcare Ltd (Zydus)
CompositionSOFOSBUVIR 400 MG & LEDIPASVIR 90 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
FormTablet
Shelf life2021
Other Details:

  • Ledihep is a prescription drug and should be used under proper medical guidance and advice
  • The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers

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Sofovir Tablet
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Sofovir Tablet

Approx. Price: Rs 3,500 / BottleGet Latest Price
Product Details:
Pack Size28 Tablets
Strength/Dose (in mg or ml)400 mg
Product TypeFinish Product
BrandSOFOVIR
ManufacturerHETERO
CompositionSOFOSBUVIR 400 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
We are extremely engaged in offering an incomparable quality Sofovir Tablet. Directly targets the hepatitis c virus to stop it from making copies of itself in the liver and makes it harder for the virus to multiply, offered tablet is processed under guidance of vendor professionals using the best quality chemical compounds and cutting edge technology. So as to offer a qualitative product, this tablet is rigorously tested on different parameters of quality. Apart from this, we provide this tablet in various packaging options so as to maintain its quality. 

Features:


  • Temper proof packing
  • No side effects
  • Safe packaging


Other Details: 7 Tablets.


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Dacihep Tablet
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Dacihep Tablet

Approx. Price: Rs 1,500 / BottleGet Latest Price
Product Details:
Packaging Size28 Tablets
Dose/Strength (ex. 1 mg or 1 ml)60 mg
Pack size28 TAB
BrandDACIHEP
ManufacturerCadila Healthcare Ltd (Zydus)
CompositionDACLATASVIR 60 MG
Other Details:

  • Dacihep is a prescription drug and should be used under proper medical guidance and advice
  • The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers
  • Keep all medicines out of the reach of children and away from pets,never share your medicines with others,and use this medication only for the indication prescribed

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Daclahep Tablet
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Daclahep Tablet

Approx. Price: Rs 1,800 / BottleGet Latest Price
Product Details:
Dose60 mg
Packaging Size28 tablets
Pack size28 TAB
BrandDACLAHEP
ManufacturerHETERO
CompositionDACLATASVIR 60 MG
We are extremely engrossed in exporting, retailing, wholesaling and supplying a premium quality Daclahep Tablet. The offered tablet is processed utilizing superior quality chemical compounds and the latest technology in compliance with industry norms. The offered tablet when used in combination with sofosbuvir may result in slowing of the heart rate. Apart from this, we offer this tablet in various packaging options so as to maintain its long shelf life.

Features:


  • 100% safe
  • Safe to consume
  • Free from impurities


Other Details: 28 Tablet


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Hepcinat Tablet
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Hepcinat Tablet

Approx. Price: Rs 3,500 / BottleGet Latest Price
Product Details:
Pack size28 TAB
BrandHEPCINAT
ManufacturerNATCO
CompositionSOFOSBUVIR 400 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
To meet the diverse demands of our precious clients, we are engaged in exporting, retailing and wholesaling an optimum quality Hepcinat Tablet. The offered tablet is used to cure people of the Hep C virus along with combination of other medications. To process this tablet, our vendors’ professionals use only high grade chemical compounds and the latest technology in sync with predefined industry quality norms. Apart from this, offered tablet is available in different packaging options as per the needs of our clients.

Features:


  • Accurate composition
  • Hygienically packed
  • Effectiveness


Other Details: 28 Tablets.



Additional Information:

  • Item Code: 400mg

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Hepcvir Tablet
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Hepcvir Tablet

Approx. Price: Rs 3,000 / BottleGet Latest Price
Product Details:
Pack Size28 Tablets
Strength/Dose (in mg or ml)400 mg
BrandHEPCVIR
ManufacturerCipla Ltd
CompositionSOFOSBUVIR 400 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
Packaging Size30 TAB
Usage/ApplicationPersonal
Packaging TypeBOTTLE
FormTablet
Manufactured ByCIPLA
We have achieved a distinct position in the market by wholesaling and exporting a superior quality Hepcvir Tablet. Used in combination with other antiviral medicines to reduce the amount of hepatitis C virus (HCV) in the body to help the liver recover, offered tablet is hygienically processed using the best quality chemical compounds and modern technology under the vigilance of vendors’ professionals in line with set industry standards. Furthermore, this tablet is tested on varied parameters by our quality examiners so as to ensure its quality. 

Features:


  • Accurate composition
  • Highly effective
  • No side effects


Other Details: 15 Tablets.


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X-VIR Tablet
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X-VIR Tablet

Approx. Price: Rs 1,400 / BottleGet Latest Price
Product Details:
Minimum Order Quantity1 Bottle
Packaging Size30 Tabets
Dose/Strength (ex. 1 mg or 1 ml)0.5 mg
Pack size30 TAB
BrandX VIR 0.5
ManufacturerNATCO
CompositionENTECAVIR 0.5
TreatmentHEPATITIS B
Prescription/Non prescriptionPrescription
Entecavir(0.5 Mg)UsesX vir 0.5 mg tablet is used in the treatment of hiv infection and chronic hepatitis bHow it worksX vir 0.5 mg tablet is an antiviral drug and belongs to class of drugs called synthetic nucleoside analogues. It works by blocking the DNA synthesis in hepatitis B virus, a process essential for the virus to grow and multiply. X vir 0.5 mg tablet thus stops the virus from spreading in the body. It does not prevent spread of HBV infections to other people.Common side effects Nausea, Rash, Allergic reaction, Dizziness, Hair loss, Headache, Indigestion, Vomiting, Fatigue, Worsening of hepatitis b (viral infection of liver), Lactic acidosis

MOQ 30 Tab


Packaging Type 30 Tablet 


Dose/Strength (ex. 1 mg or 1 ml) 0.5 mg

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  • SOFOKAST
  • SOFOKAST
SOFOKAST
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SOFOKAST

Approx. Price: Rs 4,000 / PieceGet Latest Price
Product Details:
Pack size28 TAB
BrandSOFOKAST
ManufacturerAPRAZER
CompositionSOFOSBUVIR 400 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
FormTablet
Shelf life2021
The medicinal product “Sofoskast” is treated with a chronic form of hepatitis C. Complex therapy with the use of this drug and other medications are prescribed for adult patients. The drug also treats patients with HIV and co-infections. The active component of the Sofokast tablets is sofosbuvir. They are coated and contain 400 mg of the basic substance. The package contains 28 tablets.

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  • Ledikast
  • Ledikast
Ledikast
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Ledikast

Approx. Price: Rs 5,600 / BottleGet Latest Price
Product Details:
Pack size28 TAB
BrandLEDIKAST
ManufacturerAPRAZER
CompositionSOFOSBUVIR 400 MG AND LEDIPASVIR 90 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
Dosage FormTablet
Packaging Size28

Brand Name LEDIKAST
Contents Ledipasvir and Sofosbuvir
Marketed by Aprazer Health Care
Manufactured by Natco Pharma Limited
Strength - Each film-coated tablet Contains 90 mg Ledipasvir and 400 mg Sofosbuvir
Form Tablets
Packing Pack of 28 Tablet

Each film-coated tablet contains 90 mg ledipasvir and 400 mg sofosbuvir. The tablet includes the following inactive ingredients colloidal silicon dioxide, copovidone, croscarmellose sodium, lactose monohydrate, magnesium stearate, and microcrystalline cellulose. The tablet is film-coated with a coating material containing the following inactive ingredients Yellow Oxide of Iron, polyethylene glycol, polyvinyl alcohol, talc, FD&C Blue #2 and titanium dioxide IP. -

Ledipasvir The IUPAC name for ledipasvir is Methyl [(2S)-1-{(6S)-6-[5-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2azabicyclo[2.2.1] hept-3-yl]-1H-benzimidazol-6-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4] hept-5-yl}-3-methyl-

 


2.1 Mechanism of Action

Ledikast is a fixed-dose combination of ledipasvir and sofosbuvir which are directacting antiviral agents against the hepatitis C virus.

2.2 Pharmacodynamics

Cardiac Electrophysiology

Ledipasvir at a dose of 120 mg twice daily (2.67 times the maximum recommended dosage) and sofosbuvir 400 mg (maximum recommended dosage) and 1200 mg (three times the maximum recommended dosage) does not prolong QTc in clinical trials -


2.3 Pharmacokinetics

Absorption

The pharmacokinetic properties of ledipasvir, sofosbuvir, and the predominant circulating metabolite GS-331007 have been evaluated in healthy adult subjects and in subjects with chronic hepatitis C. Following oral administration, ledipasvir median peak concentrations were observed 4 to 4.5 hours post-dose. Sofosbuvir was absorbed quickly and the peak median plasma concentration was observed ~0.8 to 1 hour post dose. Median peak plasma concentration of GS-331007 was observed between 3.5 to 4 hours post-dose.

Based on the population pharmacokinetic analysis in HCV-infected subjects, geometric mean steady-state AUC0-24 for ledipasvir (N=2113), sofosbuvir (N=1542), and GS-331007 (N=2113) were 7290, 1320, and 12,000 ng-hr/mL. Steady-state Cmax for ledipasvir, sofosbuvir, and GS-331007 were 323, 618, and 707 ng/mL. Sofosbuvir and GS-331007 AUC0-24 and Cmax were similar in healthy adult subjects and subjects with HCV infection. Relative to healthy subjects (N=191)



Ledipasvir is >99.8% bound to human plasma proteins. After a single 90 mg dose of [14C]-ledipasvir in healthy subjects, the blood to plasma ratio of [14C]-radioactivity ranged between 0.51


Sofosbuvir is approximately 61-65% bound to human plasma proteins and the binding is independent of drug concentration over the range of 1 g/mL to 20 g/mL. Protein binding of GS-331007 was minimal in human plasma. After a single 400 mg dose of [14C]-sofosbuvir in healthy subjects, the blood to plasma ratio of 14C-radioactivity was approximately 0.7.


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  • Velakast
  • Velakast
Velakast
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Velakast

Approx. Price: Rs 9,750 / PieceGet Latest Price
Product Details:
Packaging Size28
Dosage FormTablet
UsesHEPATITIS C TREATMENT
BrandVELAKAST
CompositionSOFOSBUVIR 400 MG AND VELPATASVIR 100 MG
Packaging TypeBOTTLE
FormTablets
VELAKAST is a fixed-dose combination tablet containing sofosbuvir and velpatasvir for oral administration. Sofosbuvir is a nucleotide analog HCV NS5B polymerase inhibitor and velpatasvir is an NS5A inhibitor. Each tablet contains 400 mg sofosbuvir and 100 mg velpatasvir. The tablets include the following inactive ingredients: copovidone, croscarmellose sodium, magnesium stearate, and microcrystalline cellulose. The tablets are film-coated with a coating material containing the following inactive ingredients: Titanium Dioxide IP and Brilliant Blue FCF, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide.
Effect of the drug
Thanks to the powerful composition of the drug, Velakast APRAZER HEALTHCARE is widely used to fight the hepatitis C virus of genotypes 1-6. The drug may be given as a monotherapy or for combined treatment with or without cirrhosis. The high effectiveness of the drug against all genotypes of HCV is due to the presence in its composition:
Sofosbuvir: The IUPAC name for sofosbuvir is (S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5(2,4-dioxo-3,4-dihydropyrimidin- 1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran- 2yl)methoxy  (phenoxy)phosphorylamino)propanoate. It has a molecular formula of C22H29FN3 O9 P and a molecular weight of 529.45. Sofosbuvir is a white to off-white crystalline solid with a solubility of at least 2 mg/mL across the pH range of 2–7.7 at 37°C and is slightly soluble in water.
Velpatasvir: The IUPAC name for velpatasvir is Methyl {(1R)-2-[(2S,4S)-2-(5-{2[(2S,5S)-1-{(2S)-2-[(methoxycarbonyl) amino]-3-methylbutanoyl}-5-methylpyrrolidin-2-yl]1,11-dihydro[2]benzopyrano[4′,3′:6,7]naphtho[1,2-d]imidazol-9- yl}-1H-imidazol-2-yl)-4(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate. It has a molecular formula of C49H54 N8 O8 and a molecular weight of 883.0. Velpatasvir is practically insoluble (less than 0.1 mg/mL) above pH 5, slightly soluble (3.6 mg/mL) at pH 2, and soluble (greater than 36 mg/mL) at pH 1.2.
Mechanism of Action
VELAKAST is a fixed-dose combination of sofosbuvir and velpatasvir which are direct-acting antiviral agents against the hepatitis C virus Sofosbuvir is an inhibitor of the HCV NS5B RNA-dependent RNA polymerase, which is required for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate (GS-461203), which can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. In a biochemical assay, GS-461203 inhibited the polymerase activity of the recombinant NS5B from HCV genotype 1b, 2a, 3a and 4a with an IC50 value ranging from 0.36 to 3.3 micromolar. GS-461203 is neither an inhibitor of human DNA and RNA polymerases nor an inhibitor of mitochondrial RNA polymerase. Velpatasvir is an inhibitor of the HCV NS5A protein, which is required for viral replication. Resistance selection in cell culture and cross-resistance studies indicates velpatasvir targets NS5A as its mode of action.
OVERDOSAGE
No specific antidote is available for overdose with VELAKAST. If overdose occurs the patient must be monitored for evidence of toxicity. Treatment of overdose with VELAKAST consists of general supportive measures including monitoring of vital signs as well as observation of the clinical status of the patient. Hemodialysis can efficiently remove the predominant circulating metabolite of sofosbuvir, GS-331007, with an extraction ratio of 53%. Hemodialysis is unlikely to result in significant removal of velpatasvir since velpatasvir is highly bound to plasma protein.
HOW SUPPLIED AND STORAGE
Each bottle contains 28 tablets and is closed with a child-resistant closure. Storage: Store below 30°C

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Myhep All
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Myhep All

Approx. Price: Rs 10,000 / BottleGet Latest Price
Product Details:
Minimum Order Quantity1 Bottle
Pack size28 TAB
BrandMYHEP ALL
ManufacturerMYLAN
CompositionSOFOSBUVIR 400 MG & VELPATASVIR 100 MG
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
FormTablet
Shelf life2021
  • Brand Name - Myhep All
  • Generic - Sofosbuvir and Velpatasvir
  • Strength - Sofosbuvir 400 Mg and Velpatasvir 100 Mg
  • Form - Tablets
  • Packing - 1 X 28
  • Manufactured by - Mylan Pharmaceuticals

Additional Information:
  • Delivery Time: 1 DAY DELIVERY
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Ribasure
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Ribasure

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Product Details:
BrandRIBASURE
CompositionRIBAVIRIN
Drug NameRIBASURE
Usage/ApplicationORAL TABLETS
Strength200 MG
Manufactured ByAPRAZER
Ribasure Capsule is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.

Additional Information:
  • Packaging Details: 140 CAPSULES
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HEPCIVIR
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HEPCIVIR

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Product Details:
Pack size28 TABLETS
BrandHEPCIVIR
ManufacturerCipla Ltd
CompositionSofosbuvir 400 mg
TreatmentHepatitis c
Prescription/Non prescriptionPrescription
FormTablet
Hepcivir 400mg Tablet containing the active ingredient sofosbuvir is a nucleotide polymerase inhibitor type of antiviral medication used to treat Hepatitis C. Hepcivir Tablets must be used in combination with other antiviral medicines to reduce the amount of hepatitis C virus (HCV) in the body to help the liver recover. Chronic hepatitis C infections can cause serious liver problems such as liver cancer or cirrhosis (scarring). Patients with HIV or liver cancer and are going to have a liver transplant may also use the drug to decrease the risk of reinfection after the transplant.

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  • Packaging Details: 28 tablets
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Myhep
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Myhep

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Product Details:
Pack size28 TABS
BrandMYLAN
ManufacturerMYLAN
CompositionSOFOSBUVIR DACLATASVIR
TreatmentHEP C
Prescription/Non prescriptionPrescription
FormTablet
MyHep 400mg (Sofosbuvir) is used for treatment of hepatitis C virus infection.
MyHep is available as a 400 mg tableT.

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  • Packaging Details: 28 TABLETS
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My Dekla
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My Dekla

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Product Details:
Pack size28 TABLETS
BrandMY DEKLA
ManufacturerMYLAN
CompositionDACLATASVIR
TreatmentHEPATITIS C
Prescription/Non prescriptionPrescription
FormTablet
MyDekla 60 Tablet is an antiviral medication used for the treatment of chronic hepatitis C in adults. It is normally used in a combination with sofosbuvir, with or without ribavirin. However, this medicine is not recommended for use as a preventive option for the spread of hepatitis C.

Additional Information:
  • Packaging Details: 28 TABLETS
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Ledviclear
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Ledviclear

Approx. Price: Rs 6,000 / BottleGet Latest Price
Product Details:
Strength/Dose (in mg or ml)Sofosbuvir 400 mg, Ledipasvir 90 mg
Pack Size28 Tablets
Sofosbuvir(400mg)Uses Sofosbuvir is used in combination with other antiviral drugs for treatment of patients with viral infection that damages the liver (Hepatitis C) including those patients who have human immunodeficiency virus (HIV) infection or liver cancer or are awaiting a liver transplant. How it works Sofosbuvir is an antiviral drug that belongs to a class of medicines called nucleotide polymerase inhibitors. It inhibits an enzyme RNA polymerase which is essential for viral replication and thus decreases the amount of Hepatitis C virus in the body thereby resulting in less liver damage and improved liver function.Common side effects Nausea, Pale colored skin, Back pain, Chills, Diarrhoea, Fatigue, Weakness, Fever, Headache, Insomnia, Loss of appetite, Mouth ulcer, Muscle pain, Muscle cramp, Rash, Itching, Sores, Ulcer

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Velasof
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Velasof

Approx. Price: Rs 10,000 / BoxGet Latest Price
Product Details:
Strength/Dose (in mg or ml)Sofosbuvir 400 mg & velpatasvir 100 mg
Pack Size28 Tab

Velpatasvir Sofosbuvir ( Tab Velasof ) by Hetero is a combination of sofosbuvir and velpatasvir and is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. It is also used with another antiviral medication (ribavirin). These drugs work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover.

Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

Sofosbuvir 400 mg Velpatasvir 100 mg Indication :

Velasof ( Sofosbuvir 400 mg velpatasvir 100 mg) is used alone or with ribavirin to treat chronic hepatitis C. Sofosbuvir is in a class of antiviral medications called nucleotide hepatitis C virus (HCV) NS5B polymerase inhibitors. Velpatasvir is in a class of antiviral medications called HCV NS5A replication complex inhibitors.

The combination of sofosbuvir and velpatasvir works by stopping the virus that causes hepatitis C from spreading inside the body.


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Sofocure Tablets
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Sofocure Tablets

Approx. Price: Rs 3,200 / BottleGet Latest Price
Product Details:
Strength/Dose (in mg or ml)400 mg
Pack Size28 Tablets
Product TypeFinish Product
Other Details:

  • Sofocure is a prescription drug and should be used under proper medical guidance and advice.

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Resof
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Resof

Approx. Price: Rs 4,000 / BoxGet Latest Price
Product Details:
Strength/Dose (in mg or ml)400 mg
Pack Size28 Tablets
Product TypeFinish Product
Sofosbuvir(400 Mg)Uses Resof 400mg tablet is used in combination with other antiviral drugs for treatment of patients with viral infection that damages the liver (Hepatitis C) including those patients who have human immunodeficiency virus (HIV) infection or liver cancer or are awaiting a liver transplant.How it works Resof 400mg tablet is an antiviral drug that belongs to a class of medicines called nucleotide polymerase inhibitors. It inhibits an enzyme RNA polymerase which is essential for viral replication and thus decreases the amount of Hepatitis C virus in the body thereby resulting in less liver damage and improved liver function.Common side effectsNausea, Pale colored skin, Back pain, Chills, Diarrhoea, Fatigue, Weakness, Fever, Headache, Insomnia, Loss of appetite, Mouth ulcer, Muscle pain, Muscle cramp, Rash, Itching, Sores, Ulcer

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Resof-L
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Resof-L

Approx. Price: Rs 6,500 / BottleGet Latest Price
Product Details:
Strength/Dose (in mg or ml)400 mg
Pack Size28 Tablets
Product TypeFinish Product
Ledipasvir(90mg)Uses
Common side effects Sofosbuvir(400mg)Uses Sofosbuvir is used in the treatment of chronic hepatitis cHow it works Sofosbuvir is an antiviral drug that belongs to a class of medicines called nucleotide polymerase inhibitors. It inhibits an enzyme RNA polymerase which is essential for viral replication and thus decreases the amount of Hepatitis C virus in the body thereby resulting in less liver damage and improved liver function.Common side effects Nausea, Pale colored skin, Back pain, Chills, Diarrhoea, Fatigue, Weakness, Fever, Headache, Insomnia, Loss of appetite, Mouth ulcer, Muscle pain, Muscle cramp, Rash, Itching, Sores, Ulcer

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MyDekla
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MyDekla

Approx. Price: Rs 1,500 / BottleGet Latest Price
Product Details:
Packaging Size28 tablets
Dose/Strength (ex. 1 mg or 1 ml)60 mg
With our in-depth knowledge and rich industry experience in this field, we are highly engaged in exporting, retailing, wholesaling and supplying a qualitative Mydekla Tablet for our esteemed clients. Processed employing advanced technology and using premium quality chemical compounds, offered tablet should only be used under proper medical guidance and advice. In order to maintain the effectiveness, our quality examiners test this tablet on various parameters. 

Features:

  • Highly effective
  • Long shelf life
  • Balanced composition


Other Details: 28 Tablets.


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Instgra
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Instgra

Approx. Price: Rs 3,000 / BottleGet Latest Price
Product Details:
DoseDolutegravir 50mg
Packaging Size30 Tablets

Dolutegravir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 12 years of age and older and weighing at least 88 pounds (40 kilograms). Dolutegravir is always used in combination with other HIV medicines.

Dolutegravir belongs to a class (group) of HIV drugs called integrase inhibitors. Integrase inhibitors block an HIV enzyme called integrase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking integrase, integrase inhibitors prevent HIV from multiplying and can reduce the amount of HIV in the body. HIV medicines can’t cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission


What side effects can dolutegravir cause?

Dolutegravir may cause side effects. Most side effects from dolutegravir are manageable, but a few can be serious. Serious side effects of dolutegravir include allergic reactions and liver problems. (See the WARNING above.)Other possible side effects of dolutegravir include:

Changes in liver test results. People with a history of HBV or HCV may have an increased risk of developing new or worsening changes in certain liver test results during treatment with dolutegravir.
Changes in body fat (including gain or loss of fat).

Immune reconstitution inflammatory syndrome (IRIS), a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.
Trouble sleeping.
Tiredness.
Headache.
Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of dolutegravir. To learn more about possible side effects of dolutegravir, read the drug label or package insert or talk to your health care provider or pharmacist.The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to dolutegravir.

 

30 Tab


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